Assay Detail
Binding
CHEMBL695235
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Inhibitory activity against HIV-1 protease
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent, orally bioavailable HIV-1 protease inhibitors containing noncoded D-amino acids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.68 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95228 | — | — | 1 | 9.68 |
| CHEMBL98954 | — | — | 1 | 9.66 |
| CHEMBL49002 | — | — | 1 | 9.40 |
| CHEMBL99357 | — | — | 1 | 9.38 |
| CHEMBL100089 | — | — | 1 | 9.30 |
| CHEMBL316694 | — | — | 1 | 9.30 |
| CHEMBL317793 | — | — | 1 | 9.22 |
| CHEMBL263423 | — | — | 1 | 9.15 |
| CHEMBL431455 | — | — | 1 | 8.92 |
| CHEMBL432784 | — | — | 1 | 8.80 |
| CHEMBL415318 | — | — | 1 | 8.77 |
| CHEMBL328205 | — | — | 1 | 8.74 |
| CHEMBL317160 | — | — | 1 | 8.74 |
| CHEMBL318668 | — | — | 1 | 8.70 |
| CHEMBL318285 | — | — | 1 | 8.68 |
| CHEMBL418978 | — | — | 1 | 8.29 |
| CHEMBL99081 | — | — | 1 | 8.22 |
| CHEMBL430863 | — | — | 1 | 8.00 |
| CHEMBL99878 | — | — | 1 | 8.00 |
| CHEMBL99774 | — | — | 1 | 7.62 |
| CHEMBL98709 | — | — | 1 | 7.30 |
| CHEMBL330620 | — | — | 1 | 7.07 |
| CHEMBL100040 | — | — | 1 | - |
| CHEMBL98589 | — | — | 1 | - |
| CHEMBL99267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95228 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL98954 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL49002 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL99357 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL100089 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL316694 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL317793 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL263423 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL431455 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL432784 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL415318 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL328205 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL317160 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL318668 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL318285 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL418978 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL99081 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL430863 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL99878 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL99774 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL98709 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL330620 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL100040 | — | IC50 | < | 0.2 | nM | - |
| CHEMBL98589 | — | IC50 | < | 0.2 | nM | - |
| CHEMBL99267 | — | IC50 | < | 0.2 | nM | - |