Assay Detail
Functional
CHEMBL695313
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Inhibition of Hs 27 human fibroblast cell proliferation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HS27 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.48 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.29 |
| CHEMBL125401 | — | — | 1 | 6.07 |
| CHEMBL129396 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL125401 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL129396 | — | IC50 | = | 860.0 | nM | 6.07 |