Assay Detail
Functional
CHEMBL695428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for induction of cellular death in Human breast 401NL tumor cell line in Propidium Iodide Monolayer Assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MAXF401 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.89 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL115488 | — | — | 1 | 7.70 |
| CHEMBL115360 | — | — | 1 | 6.68 |
| CHEMBL321632 | — | — | 1 | 6.62 |
| CHEMBL112385 | — | — | 1 | 6.52 |
| CHEMBL324797 | — | — | 1 | 5.82 |
| CHEMBL116173 | — | — | 1 | - |
| CHEMBL112192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL115488 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL115360 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL321632 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL112385 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL324797 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL116173 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL112192 | — | IC50 | < | 10.0 | nM | - |