Assay Detail
Functional
CHEMBL695429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor potency on human breast MCF-7 cell lines.
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Structure-activity relationships for mitomycin C and mitomycin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.31 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48060 | — | — | 1 | 9.68 |
| CHEMBL75775 | — | — | 1 | 9.29 |
| CHEMBL298359 | MITOMYCIN A | 3.0 | 1 | 9.20 |
| CHEMBL75298 | — | — | 1 | 9.14 |
| CHEMBL75060 | — | — | 1 | 8.96 |
| CHEMBL308944 | — | — | 1 | 8.95 |
| CHEMBL73968 | — | — | 1 | 8.88 |
| CHEMBL274951 | — | — | 1 | 8.85 |
| CHEMBL72435 | — | — | 1 | 8.85 |
| CHEMBL76045 | — | — | 1 | 8.81 |
| CHEMBL76179 | — | — | 1 | 8.75 |
| CHEMBL73678 | — | — | 1 | 8.73 |
| CHEMBL419265 | — | — | 1 | 8.57 |
| CHEMBL414876 | — | — | 1 | 8.55 |
| CHEMBL75851 | — | — | 1 | 8.50 |
| CHEMBL46352 | — | — | 1 | 8.43 |
| CHEMBL46097 | — | — | 1 | 8.41 |
| CHEMBL75345 | — | — | 1 | 8.36 |
| CHEMBL296143 | — | — | 1 | 8.09 |
| CHEMBL423673 | — | — | 1 | 7.88 |
| CHEMBL73159 | — | — | 1 | 7.79 |
| CHEMBL42099 | — | — | 1 | 7.77 |
| CHEMBL307151 | — | — | 1 | 7.64 |
| CHEMBL36171 | — | — | 1 | 7.64 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.49 |
| CHEMBL310493 | — | — | 1 | 7.45 |
| CHEMBL3707108 | — | — | 1 | 7.44 |
| CHEMBL75394 | — | — | 1 | 7.14 |
| CHEMBL416827 | — | — | 1 | 7.09 |
| CHEMBL72796 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48060 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL75775 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL298359 | MITOMYCIN A | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL75298 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL75060 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL308944 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL73968 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL274951 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL72435 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL76045 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL76179 | — | IC50 | = | 1.77 | nM | 8.75 |
| CHEMBL73678 | — | IC50 | = | 1.87 | nM | 8.73 |
| CHEMBL419265 | — | IC50 | = | 2.66 | nM | 8.57 |
| CHEMBL414876 | — | IC50 | = | 2.84 | nM | 8.55 |
| CHEMBL75851 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL46352 | — | IC50 | = | 3.69 | nM | 8.43 |
| CHEMBL46097 | — | IC50 | = | 3.92 | nM | 8.41 |
| CHEMBL75345 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL296143 | — | IC50 | = | 8.22 | nM | 8.09 |
| CHEMBL423673 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL73159 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL42099 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL307151 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL36171 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL310493 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL3707108 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL75394 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL416827 | — | IC50 | = | 80.6 | nM | 7.09 |
| CHEMBL72796 | — | IC50 | = | 132.5 | nM | 6.88 |