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Assay Detail

CHEMBL695469

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for cytotoxicity against HOP-92 cell lines.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HOP-92
Confidence 1 — Organism
Curated By Intermediate

Target

HOP-92 (CHEMBL613889)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel imidazothioxanthones: Synthesis, DNA binding and cytotoxicity
Varvaresou A, Tsotinis A, Siatra-Papastaikoudi T, Papadaki-Valiraki A, Thurston D, Jenkins T, Kelland L
Bioorg Med Chem Lett (1996) 6 : 865 -870
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 5.05 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL171004 1 6.44
CHEMBL172337 1 4.89
CHEMBL171026 1 4.80
CHEMBL434104 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL171004 IC50 = 360.0 nM 6.44
CHEMBL172337 IC50 = 12800.0 nM 4.89
CHEMBL171026 IC50 = 15900.0 nM 4.80
CHEMBL434104 IC50 = 87500.0 nM 4.06