Assay Detail
Functional
CHEMBL695476
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In vitro cytotoxic effect on HOS cancer cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological activity of olomoucine II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.77 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1094304 | OLOMOUCINE II | — | 1 | 5.20 |
| CHEMBL83320 | — | — | 1 | 5.08 |
| CHEMBL114499 | — | — | 1 | 4.96 |
| CHEMBL323393 | — | — | 1 | 4.92 |
| CHEMBL84944 | — | — | 1 | 4.92 |
| CHEMBL440517 | — | — | 1 | 4.89 |
| CHEMBL419931 | — | — | 1 | 4.76 |
| CHEMBL23327 | PURVALANOLA | — | 1 | 4.66 |
| CHEMBL113515 | — | — | 1 | 4.58 |
| CHEMBL111971 | — | — | 1 | 4.58 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.50 |
| CHEMBL83980 | BOHEMINE | — | 1 | 4.24 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1094304 | OLOMOUCINE II | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL83320 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL114499 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL323393 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL84944 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL440517 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL419931 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL23327 | PURVALANOLA | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL113515 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL111971 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL83980 | BOHEMINE | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 149000.0 | nM | - |