Assay Detail
Functional
CHEMBL695495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in non-NTR-expressing human ovarian carcinoma cell line (SKOV).
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ovarian cancer cell line |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.05 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288377 | — | — | 1 | 9.70 |
| CHEMBL37705 | — | — | 1 | 8.96 |
| CHEMBL314487 | — | — | 1 | 7.89 |
| CHEMBL316382 | — | — | 1 | 7.23 |
| CHEMBL84463 | — | — | 1 | 7.21 |
| CHEMBL84381 | — | — | 1 | 7.06 |
| CHEMBL314247 | — | — | 1 | 6.97 |
| CHEMBL314246 | — | — | 1 | 6.94 |
| CHEMBL311087 | — | — | 1 | 6.84 |
| CHEMBL313563 | — | — | 1 | 6.82 |
| CHEMBL311195 | — | — | 1 | 6.80 |
| CHEMBL79354 | — | — | 1 | 6.72 |
| CHEMBL78019 | — | — | 1 | 6.65 |
| CHEMBL83545 | — | — | 1 | 6.65 |
| CHEMBL311598 | — | — | 1 | 6.11 |
| CHEMBL23612 | — | — | 1 | 4.24 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288377 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL37705 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL314487 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL316382 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL84463 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL84381 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL314247 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL314246 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL311087 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL313563 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL311195 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL79354 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL78019 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL83545 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL311598 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL23612 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 174000.0 | nM | - |