Assay Detail
Functional
CHEMBL695556
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Inhibition of Hep-2 human larynx carcinoma cell proliferation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEp-2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.47 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296682 | MERIDIANIN E | — | 1 | 5.96 |
| CHEMBL296271 | — | — | 1 | 5.75 |
| CHEMBL46440 | MERIDIANIN D | — | 1 | 5.14 |
| CHEMBL44541 | MERIDIANIN C | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296682 | MERIDIANIN E | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL296271 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL46440 | MERIDIANIN D | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 9700.0 | nM | 5.01 |