Assay Detail
Functional
CHEMBL695676
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Compound was tested in vitro for anticellular activity against HeLa S3 cell growth at 1-hour exposure.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New water-soluble duocarmycin derivatives: synthesis and antitumor activity of A-ring pyrrole compounds bearing beta-heteroarylacryloyl groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.25 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348326 | — | — | 1 | 9.30 |
| CHEMBL159124 | — | — | 1 | 8.60 |
| CHEMBL101995 | — | — | 1 | 8.54 |
| CHEMBL158368 | — | — | 1 | 8.48 |
| CHEMBL161770 | — | — | 1 | 8.01 |
| CHEMBL545580 | — | — | 1 | 6.05 |
| CHEMBL541110 | — | — | 1 | 5.96 |
| CHEMBL538554 | — | — | 1 | 5.89 |
| CHEMBL539574 | — | — | 1 | 5.89 |
| CHEMBL542770 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348326 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL159124 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL101995 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL158368 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL161770 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL545580 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL541110 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL538554 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL539574 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL542770 | — | IC50 | = | 1800.0 | nM | 5.75 |