Assay Detail
Functional
CHEMBL695679
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Tested in vitro against HIV-1 104pre from HeLa-CD4-LT4-beta gal-cells using MAGI assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.88 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322215 | — | — | 1 | 9.02 |
| CHEMBL2368072 | — | — | 1 | 8.72 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.70 |
| CHEMBL2368082 | — | — | 1 | 8.70 |
| CHEMBL607878 | — | — | 1 | 8.32 |
| CHEMBL2368083 | — | — | 1 | 8.24 |
| CHEMBL2012670 | — | — | 1 | 8.17 |
| CHEMBL2368076 | — | — | 1 | 6.44 |
| CHEMBL2368078 | — | — | 1 | 6.40 |
| CHEMBL2368070 | — | — | 1 | 6.08 |
| CHEMBL2368084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322215 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL2368072 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2368082 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL607878 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2368083 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL2012670 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2368076 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2368078 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2368070 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2368084 | — | EC50 | = | 132000.0 | nM | - |