Assay Detail
Functional
CHEMBL695682
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In vitro for its inhibitory activity against MRP1-transfected HeLa-T5 cell line in the presence of doxorubicin
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa-T5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.62 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168831 | — | — | 1 | 6.19 |
| CHEMBL172119 | — | — | 1 | 6.05 |
| CHEMBL554924 | — | — | 1 | 5.95 |
| CHEMBL354935 | — | — | 1 | 5.89 |
| CHEMBL434490 | — | — | 1 | 5.83 |
| CHEMBL171614 | — | — | 1 | 5.75 |
| CHEMBL170624 | — | — | 1 | 5.75 |
| CHEMBL170699 | — | — | 1 | 5.68 |
| CHEMBL355346 | — | — | 1 | 5.64 |
| CHEMBL169765 | — | — | 1 | 5.50 |
| CHEMBL169857 | — | — | 1 | 5.43 |
| CHEMBL354544 | — | — | 1 | 5.40 |
| CHEMBL434871 | — | — | 1 | 5.39 |
| CHEMBL172059 | — | — | 1 | 5.31 |
| CHEMBL170545 | — | — | 1 | 5.10 |
| CHEMBL169803 | — | — | 1 | 5.00 |
| CHEMBL171087 | — | — | 1 | - |
| CHEMBL171665 | — | — | 1 | - |
| CHEMBL171726 | — | — | 1 | - |
| CHEMBL352527 | — | — | 1 | - |
| CHEMBL354369 | — | — | 1 | - |
| CHEMBL354582 | — | — | 1 | - |
| CHEMBL355843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168831 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL172119 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL554924 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL354935 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL434490 | — | EC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL171614 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL170624 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL170699 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL355346 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL169765 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL169857 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL354544 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL434871 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL172059 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL170545 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL169803 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL171087 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL171665 | — | EC50 | >> | 10000.0 | nM | - |
| CHEMBL171726 | — | EC50 | >> | 10000.0 | nM | - |
| CHEMBL352527 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL354369 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL354582 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL355843 | — | EC50 | > | 10000.0 | nM | - |