Assay Detail
Functional
CHEMBL695685
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In vitro inhibitory activity against HeLa/KB cells using XTT proliferation assay.
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.40 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140363 | — | — | 1 | 7.96 |
| CHEMBL141508 | — | — | 1 | 7.72 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.64 |
| CHEMBL343288 | — | — | 1 | 7.58 |
| CHEMBL140681 | — | — | 1 | 7.54 |
| CHEMBL141056 | — | — | 1 | 7.52 |
| CHEMBL141151 | — | — | 1 | 7.52 |
| CHEMBL141904 | — | — | 1 | 7.44 |
| CHEMBL141007 | — | — | 1 | 7.23 |
| CHEMBL140220 | — | — | 1 | 7.17 |
| CHEMBL337597 | — | — | 1 | 7.00 |
| CHEMBL142075 | — | — | 1 | 7.00 |
| CHEMBL138391 | — | — | 1 | 7.00 |
| CHEMBL140223 | — | — | 1 | 6.66 |
| CHEMBL139665 | — | — | 1 | 6.57 |
| CHEMBL414618 | — | — | 1 | 6.57 |
| CHEMBL141525 | — | — | 1 | 6.47 |
| CHEMBL141270 | — | — | 1 | 6.43 |
| CHEMBL139143 | — | — | 1 | 6.42 |
| CHEMBL139889 | — | — | 1 | 6.42 |
| CHEMBL140537 | — | — | 1 | 6.14 |
| CHEMBL140777 | — | — | 1 | 6.04 |
| CHEMBL140680 | — | — | 1 | 5.92 |
| CHEMBL141242 | — | — | 1 | 5.88 |
| CHEMBL140778 | — | — | 1 | 5.46 |
| CHEMBL141235 | — | — | 1 | 5.42 |
| CHEMBL141225 | — | — | 1 | 5.25 |
| CHEMBL139194 | — | — | 1 | 5.19 |
| CHEMBL140047 | — | — | 1 | 5.19 |
| CHEMBL141171 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140363 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL141508 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL107 | COLCHICINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL343288 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL140681 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL141056 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL141151 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL141904 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL141007 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL140220 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL138391 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL142075 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL337597 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL140223 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL414618 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL139665 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL141525 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL141270 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL139143 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL139889 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL140537 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL140777 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL140680 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL141242 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL140778 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL141235 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL141225 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL139194 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL140047 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL141171 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL141009 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL141317 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL140662 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL141905 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL140955 | — | IC50 | > | 10300.0 | nM | - |
| CHEMBL140818 | — | IC50 | > | 10500.0 | nM | - |
| CHEMBL142146 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL141316 | — | IC50 | > | 10900.0 | nM | - |
| CHEMBL142088 | — | IC50 | > | 12100.0 | nM | - |
| CHEMBL139195 | — | IC50 | > | 12700.0 | nM | - |
| CHEMBL140224 | — | IC50 | > | 8600.0 | nM | - |
| CHEMBL139644 | — | IC50 | > | 9500.0 | nM | - |
| CHEMBL138474 | — | IC50 | > | 10400.0 | nM | - |
| CHEMBL138062 | — | IC50 | > | 9800.0 | nM | - |