Assay Detail
Functional
CHEMBL695689
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Compound was evaluated for toxicity against HeLa S3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,17 beta-Dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-trienes: synthesis, rearrangement, cytotoxicity, and estrogen-receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.21 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1575 | ESTRAMUSTINE | 3.0 | 1 | 5.47 |
| CHEMBL290210 | VERNOLEPIN | — | 1 | 5.46 |
| CHEMBL1627359 | — | — | 1 | 5.19 |
| CHEMBL1627360 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1575 | ESTRAMUSTINE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL290210 | VERNOLEPIN | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1627359 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1627360 | — | IC50 | = | 18600.0 | nM | 4.73 |