Assay Detail
Functional
CHEMBL695699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for induction of cellular death in Human lung LXF 629L tumor cell line in Propidium Iodide Monolayer Assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LXF 629L |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.49 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112192 | — | — | 1 | 7.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL112385 | — | — | 1 | 6.89 |
| CHEMBL115360 | — | — | 1 | 6.58 |
| CHEMBL321632 | — | — | 1 | 6.14 |
| CHEMBL115488 | — | — | 1 | 5.70 |
| CHEMBL324797 | — | — | 1 | 5.68 |
| CHEMBL116173 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112192 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL112385 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL115360 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL321632 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL115488 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL324797 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL116173 | — | IC50 | < | 10.0 | nM | - |