Assay Detail
Functional
CHEMBL695865
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Inhibitory concentration of the drug resulting in inhibition of cell growth to 50% of controls in HT-29 (human colon)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.64 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30424 | — | — | 1 | 10.10 |
| CHEMBL31879 | — | — | 1 | 9.82 |
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 9.82 |
| CHEMBL30232 | — | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30424 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL31879 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL31400 | ELINAFIDE | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL30232 | — | IC50 | = | 1.5 | nM | 8.82 |