Assay Detail
Binding
CHEMBL695893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Histone deacetylase 8 (HDAC8) of HeLa nuclear extracts
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.64 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.54 |
| CHEMBL137875 | — | — | 1 | 6.19 |
| CHEMBL140525 | — | — | 1 | 6.16 |
| CHEMBL141909 | — | — | 1 | 6.11 |
| CHEMBL336935 | — | — | 1 | 6.10 |
| CHEMBL139192 | — | — | 1 | 5.55 |
| CHEMBL139193 | — | — | 1 | 5.40 |
| CHEMBL141082 | — | — | 1 | 5.17 |
| CHEMBL343717 | — | — | 1 | 5.16 |
| CHEMBL141885 | — | — | 1 | 5.01 |
| CHEMBL337584 | — | — | 1 | 4.66 |
| CHEMBL138293 | — | — | 1 | - |
| CHEMBL138626 | — | — | 1 | - |
| CHEMBL138090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL137875 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL140525 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL141909 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL336935 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL139192 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL139193 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL141082 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL343717 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL141885 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL337584 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL138293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL138626 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL138090 | — | IC50 | > | 100000.0 | nM | - |