Assay Detail
Functional
CHEMBL696021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of PLS- induced TNF-alpha production in human whole blood (HWB)
17
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.27 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112296 | — | — | 1 | 7.70 |
| CHEMBL2112295 | — | — | 1 | 7.70 |
| CHEMBL276559 | — | — | 2 | 7.22 |
| CHEMBL81491 | — | — | 1 | 7.22 |
| CHEMBL310303 | — | — | 1 | 7.05 |
| CHEMBL199015 | — | — | 1 | 7.05 |
| CHEMBL78806 | — | — | 1 | 6.92 |
| CHEMBL78439 | — | — | 2 | 6.70 |
| CHEMBL2112294 | — | — | 1 | 6.58 |
| CHEMBL417776 | — | — | 2 | 6.19 |
| CHEMBL61191 | — | — | 1 | 5.93 |
| CHEMBL383762 | — | — | 1 | 5.58 |
| CHEMBL32442 | CDP840 | — | 1 | 4.79 |
| CHEMBL82663 | SIBENADET | 2.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112295 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2112296 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL276559 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL81491 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL310303 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL199015 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL78806 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL78439 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2112294 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL417776 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL61191 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL383762 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL276559 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL417776 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL32442 | CDP840 | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL78439 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL82663 | SIBENADET | IC50 | = | 18000.0 | nM | 4.75 |