Assay Detail
Functional
CHEMBL696022
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In vitro inhibitory activity was determined against human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.95 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199015 | — | — | 1 | 7.05 |
| CHEMBL310303 | — | — | 1 | 7.00 |
| CHEMBL61191 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199015 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL310303 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL61191 | — | IC50 | = | 160.0 | nM | 6.80 |