Assay Detail
Binding
CHEMBL696067
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Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) protease
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Conformationally constrained HIV-1 protease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.06 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319408 | — | — | 1 | 10.22 |
| CHEMBL357039 | — | — | 1 | 8.74 |
| CHEMBL146361 | — | — | 1 | 7.85 |
| CHEMBL146875 | — | — | 1 | 7.77 |
| CHEMBL148090 | — | — | 1 | 7.46 |
| CHEMBL2062145 | — | — | 1 | 7.43 |
| CHEMBL356749 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319408 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL357039 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL146361 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL146875 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL148090 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2062145 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL356749 | — | IC50 | = | 111.0 | nM | 6.96 |