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Assay Detail

CHEMBL696157

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
concentration required to inhibit VSV-induced cytopathicity by 50% in HeLa cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type HeLa
Confidence 1 — Organism
Curated By Intermediate

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).
Robins MJ, Wnuk SF, Yang X, Yuan CS, Borchardt RT, Balzarini J, De Clercq E.
J Med Chem (1998) 41 : 3857 -3864
PubMed 9748360 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 4.35 4.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL608943 1 4.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL608943 EC50 = 45000.0 nM 4.35