Assay Detail
Functional
CHEMBL696288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hepatitis B virus replication in the HepAD38 cell line.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.97 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 7.52 |
| CHEMBL91037 | — | — | 1 | 5.25 |
| CHEMBL91663 | — | — | 1 | 5.14 |
| CHEMBL313225 | — | — | 1 | - |
| CHEMBL92473 | — | — | 1 | - |
| CHEMBL327341 | — | — | 1 | - |
| CHEMBL329357 | — | — | 1 | - |
| CHEMBL327630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL91037 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL91663 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL313225 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL92473 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL327341 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL329357 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL327630 | — | EC50 | > | 75000.0 | nM | - |