Assay Detail
Functional
CHEMBL696421
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 6.38 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90804 | — | — | 1 | 9.15 |
| CHEMBL90237 | — | — | 1 | 9.00 |
| CHEMBL431799 | — | — | 1 | 9.00 |
| CHEMBL90195 | — | — | 1 | 8.40 |
| CHEMBL91368 | — | — | 1 | 8.15 |
| CHEMBL88245 | — | — | 1 | 8.00 |
| CHEMBL90881 | — | — | 1 | 7.92 |
| CHEMBL93688 | — | — | 1 | 7.80 |
| CHEMBL92264 | — | — | 1 | 7.70 |
| CHEMBL88583 | — | — | 1 | 7.70 |
| CHEMBL423864 | — | — | 1 | 7.42 |
| CHEMBL88444 | — | — | 1 | 7.10 |
| CHEMBL91478 | — | — | 1 | 7.05 |
| CHEMBL328149 | — | — | 1 | 7.05 |
| CHEMBL91359 | — | — | 1 | 7.00 |
| CHEMBL90414 | — | — | 1 | 6.89 |
| CHEMBL90958 | — | — | 1 | 6.72 |
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 6.36 |
| CHEMBL88764 | — | — | 1 | 6.27 |
| CHEMBL91527 | — | — | 1 | 6.27 |
| CHEMBL92269 | — | — | 1 | 6.22 |
| CHEMBL88708 | — | — | 1 | 5.96 |
| CHEMBL91422 | — | — | 1 | 5.91 |
| CHEMBL420980 | — | — | 1 | 5.52 |
| CHEMBL330280 | — | — | 1 | 5.52 |
| CHEMBL88799 | — | — | 1 | 5.28 |
| CHEMBL91356 | — | — | 1 | 5.11 |
| CHEMBL88108 | — | — | 1 | 5.02 |
| CHEMBL314763 | — | — | 1 | 4.93 |
| CHEMBL313463 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90804 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL90237 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL431799 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL90195 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL91368 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL88245 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL90881 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL93688 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL92264 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL88583 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL423864 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL88444 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL91478 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL328149 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL91359 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL90414 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL90958 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL69139 | LIXAZINONE | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL88764 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL91527 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL92269 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL88708 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL91422 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL330280 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL420980 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL88799 | — | EC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL91356 | — | EC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL88108 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL314763 | — | EC50 | = | 11870.0 | nM | 4.93 |
| CHEMBL313463 | — | EC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL91204 | — | EC50 | = | 15520.0 | nM | 4.81 |
| CHEMBL88877 | — | EC50 | = | 29850.0 | nM | 4.53 |
| CHEMBL420618 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL91570 | — | EC50 | = | 45280.0 | nM | 4.34 |
| CHEMBL88707 | — | EC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL90120 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL90168 | — | EC50 | = | 71600.0 | nM | 4.14 |
| CHEMBL88835 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL760 | ANAGRELIDE | EC50 | = | 1.05 | PuM | - |
| CHEMBL91579 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL327580 | — | EC50 | > | 26500.0 | nM | - |
| CHEMBL313609 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL88265 | — | EC50 | > | 112000.0 | nM | - |
| CHEMBL91224 | — | EC50 | > | 106000.0 | nM | - |