Assay Detail
Binding
CHEMBL696447
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Histamine H4 receptor competition binding using [3H]Na-methylhistamine
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.43 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321860 | — | — | 1 | 6.90 |
| CHEMBL106158 | — | — | 1 | 6.65 |
| CHEMBL320331 | — | — | 1 | 6.36 |
| CHEMBL106612 | IMIFURAMINE | — | 1 | 6.05 |
| CHEMBL105803 | — | — | 1 | 5.98 |
| CHEMBL321920 | — | — | 1 | 5.60 |
| CHEMBL106913 | — | — | 1 | 5.19 |
| CHEMBL108649 | — | — | 1 | 5.09 |
| CHEMBL109130 | — | — | 1 | 4.93 |
| CHEMBL107877 | — | — | 1 | 4.92 |
| CHEMBL106931 | — | — | 1 | 4.89 |
| CHEMBL1632410 | — | — | 1 | 4.87 |
| CHEMBL106570 | — | — | 1 | 4.69 |
| CHEMBL322256 | — | — | 1 | 4.67 |
| CHEMBL320279 | — | — | 1 | 4.66 |
| CHEMBL319658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321860 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL106158 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL320331 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL106612 | IMIFURAMINE | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL105803 | — | Ki | = | 1047.13 | nM | 5.98 |
| CHEMBL321920 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL106913 | — | Ki | = | 6456.54 | nM | 5.19 |
| CHEMBL108649 | — | Ki | = | 8128.31 | nM | 5.09 |
| CHEMBL109130 | — | Ki | = | 11748.98 | nM | 4.93 |
| CHEMBL107877 | — | Ki | = | 12022.64 | nM | 4.92 |
| CHEMBL106931 | — | Ki | = | 12882.5 | nM | 4.89 |
| CHEMBL1632410 | — | Ki | = | 13489.63 | nM | 4.87 |
| CHEMBL106570 | — | Ki | = | 20417.38 | nM | 4.69 |
| CHEMBL322256 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL320279 | — | Ki | = | 21877.62 | nM | 4.66 |
| CHEMBL319658 | — | Ki | < | 100000.0 | nM | - |