Assay Detail
Binding
CHEMBL696448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-N-MC cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.17 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90019 | IMBUTAMINE | — | 1 | 7.84 |
| CHEMBL18661 | IMMEPIP | — | 1 | 7.66 |
| CHEMBL82298 | IMMETHRIDINE | — | 1 | 6.61 |
| CHEMBL78497 | — | — | 1 | 6.32 |
| CHEMBL78838 | — | — | 1 | 6.16 |
| CHEMBL309654 | — | — | 1 | 6.00 |
| CHEMBL79126 | — | — | 1 | 5.90 |
| CHEMBL311473 | — | — | 1 | 5.88 |
| CHEMBL81644 | — | — | 1 | 5.34 |
| CHEMBL82244 | — | — | 1 | 5.29 |
| CHEMBL310360 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90019 | IMBUTAMINE | Ki | = | 14.45 | nM | 7.84 |
| CHEMBL18661 | IMMEPIP | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL82298 | IMMETHRIDINE | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL78497 | — | Ki | = | 478.63 | nM | 6.32 |
| CHEMBL78838 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL309654 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL79126 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL311473 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL81644 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL82244 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL310360 | — | Ki | = | 12302.69 | nM | 4.91 |