Assay Detail
Functional
CHEMBL696464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay
85
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 85 | 7.36 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32842 | — | — | 1 | 8.15 |
| CHEMBL2093045 | — | — | 1 | 8.10 |
| CHEMBL313489 | QUIFLAPON SODIUM | -1.0 | 1 | 8.10 |
| CHEMBL349526 | — | — | 1 | 8.05 |
| CHEMBL159297 | — | — | 1 | 8.00 |
| CHEMBL159516 | — | — | 1 | 8.00 |
| CHEMBL422010 | — | — | 1 | 7.89 |
| CHEMBL350807 | — | — | 1 | 7.85 |
| CHEMBL355374 | — | — | 1 | 7.85 |
| CHEMBL348398 | — | — | 1 | 7.85 |
| CHEMBL159721 | — | — | 2 | 7.82 |
| CHEMBL161720 | — | — | 1 | 7.80 |
| CHEMBL159376 | — | — | 1 | 7.77 |
| CHEMBL160054 | — | — | 1 | 7.77 |
| CHEMBL163164 | — | — | 1 | 7.77 |
| CHEMBL346031 | — | — | 1 | 7.75 |
| CHEMBL348996 | — | — | 1 | 7.70 |
| CHEMBL161830 | — | — | 1 | 7.70 |
| CHEMBL159817 | — | — | 1 | 7.70 |
| CHEMBL2110176 | — | — | 1 | 7.70 |
| CHEMBL348939 | — | — | 1 | 7.70 |
| CHEMBL159537 | — | — | 1 | 7.70 |
| CHEMBL161965 | — | — | 1 | 7.70 |
| CHEMBL161132 | — | — | 1 | 7.70 |
| CHEMBL160015 | — | — | 1 | 7.70 |
| CHEMBL350823 | — | — | 1 | 7.68 |
| CHEMBL163544 | — | — | 1 | 7.68 |
| CHEMBL162667 | — | — | 1 | 7.68 |
| CHEMBL163806 | — | — | 1 | 7.66 |
| CHEMBL351319 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32842 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2093045 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL313489 | QUIFLAPON SODIUM | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL349526 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL159516 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL159297 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL422010 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL348398 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL350807 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL355374 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL159721 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL159721 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL161720 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL159376 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL160054 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL163164 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL346031 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL348996 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL159537 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL159817 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2110176 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL160015 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL348939 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL161132 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL161830 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL161965 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL162667 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL163544 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL350823 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL351319 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL163806 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2110173 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL163758 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL350839 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL159765 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL163222 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL163392 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL351626 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL159302 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL161584 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL159988 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL346110 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL422536 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL163931 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2110175 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL160086 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL159535 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2110174 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL423605 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL161612 | — | IC50 | = | 35.0 | nM | 7.46 |