Assay Detail
Functional
CHEMBL696712
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Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hydroxylation at C-3 of doxorubicin alters the selected phenotype of cellular drug resistance
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.13 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.68 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.79 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.10 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.03 |
| CHEMBL432707 | — | — | 1 | 6.97 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.24 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL61 | PODOFILOX | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 65.6 | nM | 7.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 79.4 | nM | 7.10 |
| CHEMBL107 | COLCHICINE | IC50 | = | 93.1 | nM | 7.03 |
| CHEMBL432707 | — | IC50 | = | 107.7 | nM | 6.97 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 576.7 | nM | 6.24 |
| CHEMBL43 | AMSACRINE | IC50 | = | 900.6 | nM | 6.04 |