Assay Detail
Binding
CHEMBL696805
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Selectivity for Kv1.3 voltage-gated K+ channel over IKCa1 [Ca2+] activated K+ channel
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 4.54 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284348 | DALFAMPRIDINE | 4.0 | 1 | 4.54 |
| CHEMBL310916 | — | — | 1 | - |
| CHEMBL432341 | — | — | 1 | - |
| CHEMBL76543 | — | — | 1 | - |
| CHEMBL308029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284348 | DALFAMPRIDINE | Kd | = | 29000.0 | nM | 4.54 |
| CHEMBL310916 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL432341 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL76543 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL308029 | — | Kd | > | 100000.0 | nM | - |