Assay Detail
Binding
CHEMBL696935
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Binding affinity against H1 receptor of guinea pig by the displacement of [3H]mepyramine, bound to membranes of CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.57 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94249 | — | — | 1 | 6.20 |
| CHEMBL90063 | — | — | 1 | 5.60 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 4.90 |
| CHEMBL417096 | IMPENTAMINE | — | 1 | - |
| CHEMBL554031 | — | — | 1 | - |
| CHEMBL92694 | — | — | 1 | - |
| CHEMBL91353 | HOMOHISTAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94249 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL90063 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL90 | HISTAMINE | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL417096 | IMPENTAMINE | Ki | = | 125892.54 | nM | - |
| CHEMBL554031 | — | Ki | = | 125892.54 | nM | - |
| CHEMBL92694 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL91353 | HOMOHISTAMINE | Ki | > | 1000000.0 | nM | - |