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Assay Detail

CHEMBL696955

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Functional
In vitro antiviral activity against human cytomegalovirus by plaque method.
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human betaherpesvirus 5
Confidence 1 — Organism
Curated By Expert

Target

Human betaherpesvirus 5 (CHEMBL371)
Type ORGANISM
Organism Human betaherpesvirus 5

Publication

Synthesis and evaluation of certain thiosangivamycin analogs as potential inhibitors of cell proliferation and human cytomegalovirus.
Krawczyk SH, Renau TE, Nassiri MR, Westerman AC, Wotring LL, Drach JC, Townsend LB.
J Med Chem (1995) 38 : 4115 -4119
PubMed 7562947 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.71 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99668 TOYOCAMYCIN 3 7.00
CHEMBL171699 1 6.40
CHEMBL132669 1 6.40
CHEMBL134202 1 6.30
CHEMBL2092972 1 6.22
CHEMBL3350229 1 6.05
CHEMBL3143103 1 5.80
CHEMBL132208 1 5.60
CHEMBL336782 1 5.57
CHEMBL609207 1 5.51
CHEMBL130555 1 5.29
CHEMBL3143096 1 5.24
CHEMBL182 GANCICLOVIR 4.0 1 5.11
CHEMBL3142825 1 4.85
CHEMBL338681 1 4.72
CHEMBL3143100 1 4.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99668 TOYOCAMYCIN IC50 = 100.0 nM 7.00
CHEMBL99668 TOYOCAMYCIN IC50 = 300.0 nM 6.52
CHEMBL132669 IC50 = 400.0 nM 6.40
CHEMBL171699 IC50 = 400.0 nM 6.40
CHEMBL134202 IC50 = 500.0 nM 6.30
CHEMBL2092972 IC50 = 600.0 nM 6.22
CHEMBL3350229 IC50 = 900.0 nM 6.05
CHEMBL3143103 IC50 = 1600.0 nM 5.80
CHEMBL99668 TOYOCAMYCIN IC50 = 1700.0 nM 5.77
CHEMBL132208 IC50 = 2500.0 nM 5.60
CHEMBL336782 IC50 = 2700.0 nM 5.57
CHEMBL609207 IC50 = 3100.0 nM 5.51
CHEMBL130555 IC50 = 5100.0 nM 5.29
CHEMBL3143096 IC50 = 5700.0 nM 5.24
CHEMBL182 GANCICLOVIR IC50 = 7700.0 nM 5.11
CHEMBL3142825 IC50 = 14000.0 nM 4.85
CHEMBL338681 IC50 = 19000.0 nM 4.72
CHEMBL3143100 IC50 = 35000.0 nM 4.46