Assay Detail
Functional
CHEMBL696979
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Inhibition of arachidonic acid-induced platelet aggregation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.44 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336617 | — | — | 1 | 6.40 |
| CHEMBL131216 | — | — | 1 | 5.68 |
| CHEMBL129921 | — | — | 1 | 5.62 |
| CHEMBL543666 | — | — | 1 | 5.43 |
| CHEMBL335492 | — | — | 1 | 5.39 |
| CHEMBL543903 | — | — | 1 | 5.35 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.30 |
| CHEMBL334831 | — | — | 1 | 4.92 |
| CHEMBL265628 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336617 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL131216 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL129921 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL543666 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL335492 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL543903 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL25 | ASPIRIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL334831 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL265628 | — | IC50 | = | 13000.0 | nM | 4.89 |