Assay Detail
Functional
CHEMBL696983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit adenosine diphosphate (ADP) induced aggregation of human platelets by 50% in vitro.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.03 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310081 | — | — | 1 | 7.52 |
| CHEMBL145956 | — | — | 1 | 7.28 |
| CHEMBL450621 | — | — | 1 | 7.11 |
| CHEMBL344544 | — | — | 1 | 7.05 |
| CHEMBL147976 | — | — | 1 | 7.03 |
| CHEMBL146393 | — | — | 1 | 6.96 |
| CHEMBL146627 | — | — | 1 | 6.96 |
| CHEMBL118402 | — | — | 1 | 6.96 |
| CHEMBL146979 | — | — | 1 | 6.92 |
| CHEMBL422486 | — | — | 1 | 6.89 |
| CHEMBL444861 | — | — | 1 | 6.82 |
| CHEMBL356363 | — | — | 1 | 6.46 |
| CHEMBL147921 | — | — | 1 | 6.25 |
| CHEMBL146417 | — | — | 1 | 6.24 |
| CHEMBL148010 | — | — | 1 | 6.13 |
| CHEMBL146721 | — | — | 1 | 6.10 |
| CHEMBL146523 | — | — | 1 | 5.99 |
| CHEMBL358154 | — | — | 1 | 5.96 |
| CHEMBL146031 | — | — | 1 | 5.92 |
| CHEMBL147877 | — | — | 1 | 5.82 |
| CHEMBL145986 | — | — | 1 | 5.64 |
| CHEMBL422132 | — | — | 1 | 5.60 |
| CHEMBL341673 | — | — | 1 | 5.58 |
| CHEMBL149424 | — | — | 1 | 5.55 |
| CHEMBL356739 | — | — | 1 | 5.44 |
| CHEMBL146784 | — | — | 1 | 5.39 |
| CHEMBL436405 | — | — | 1 | 4.96 |
| CHEMBL146323 | — | — | 1 | 4.89 |
| CHEMBL344506 | — | — | 1 | 4.52 |
| CHEMBL148183 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310081 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL145956 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL450621 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL344544 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL147976 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL146393 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL146627 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL118402 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL146979 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL422486 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL444861 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL356363 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL147921 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL146417 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL148010 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL146721 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL146523 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL358154 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL146031 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL147877 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL145986 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL422132 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL341673 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL149424 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL356739 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL146784 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL436405 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL146323 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL344506 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL148183 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL423391 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL265628 | — | IC50 | = | 62000.0 | nM | 4.21 |