Assay Detail
Binding
CHEMBL697082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human cortical Histamine 1 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.88 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318320 | — | — | 1 | 7.09 |
| CHEMBL105952 | — | — | 1 | 6.79 |
| CHEMBL105385 | — | — | 1 | 6.45 |
| CHEMBL105268 | — | — | 1 | 6.42 |
| CHEMBL102452 | — | — | 1 | 5.45 |
| CHEMBL104669 | — | — | 1 | 5.35 |
| CHEMBL25688 | — | — | 1 | 5.30 |
| CHEMBL318801 | — | — | 1 | 5.25 |
| CHEMBL105267 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318320 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL105952 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL105385 | — | Ki | = | 354.81 | nM | 6.45 |
| CHEMBL105268 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL102452 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL104669 | — | Ki | = | 4466.84 | nM | 5.35 |
| CHEMBL25688 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL318801 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL105267 | — | Ki | = | 13803.84 | nM | 4.86 |