Assay Detail
Binding
CHEMBL697083
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Binding affinity at human cortical Histamine 2 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.81 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105385 | — | — | 1 | 5.25 |
| CHEMBL105267 | — | — | 1 | 5.13 |
| CHEMBL105952 | — | — | 1 | 5.12 |
| CHEMBL318320 | — | — | 1 | 5.08 |
| CHEMBL104669 | — | — | 1 | 4.77 |
| CHEMBL318801 | — | — | 1 | 4.72 |
| CHEMBL105268 | — | — | 1 | 4.62 |
| CHEMBL102452 | — | — | 1 | 4.47 |
| CHEMBL25688 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105385 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL105267 | — | Ki | = | 7413.1 | nM | 5.13 |
| CHEMBL105952 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL318320 | — | Ki | = | 8317.64 | nM | 5.08 |
| CHEMBL104669 | — | Ki | = | 16982.44 | nM | 4.77 |
| CHEMBL318801 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL105268 | — | Ki | = | 23988.33 | nM | 4.62 |
| CHEMBL102452 | — | Ki | = | 33884.42 | nM | 4.47 |
| CHEMBL25688 | — | Ki | = | 67608.3 | nM | 4.17 |