Assay Detail
Binding
CHEMBL697099
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Displacement of [3H]mepyramine bound to membranes of CHO cells expressing guinea pig H1 receptors
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New analogs of burimamide as potent and selective histamine H3 receptor antagonists: the effect of chain length variation of the alkyl spacer and modifications of the N-thiourea substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.26 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72372 | — | — | 1 | 5.80 |
| CHEMBL310087 | — | — | 1 | 5.60 |
| CHEMBL308717 | — | — | 1 | 5.50 |
| CHEMBL305929 | — | — | 1 | 5.50 |
| CHEMBL70811 | — | — | 1 | 5.40 |
| CHEMBL72571 | — | — | 1 | 5.10 |
| CHEMBL70603 | — | — | 1 | 4.90 |
| CHEMBL72424 | — | — | 1 | 4.80 |
| CHEMBL44220 | — | — | 1 | 4.70 |
| CHEMBL12160 | BURIMAMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72372 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL310087 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL308717 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL305929 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL70811 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL72571 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL70603 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL72424 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL44220 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL12160 | BURIMAMIDE | Ki | = | 316227.77 | nM | - |