Assay Detail
Binding
CHEMBL697172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Ionotropic glutamate receptor AMPA induced depolarization in rat cortical wedge by application of 10 uM of AMPA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.80 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 6.92 |
| CHEMBL293206 | — | — | 1 | 6.30 |
| CHEMBL121771 | — | — | 1 | 6.16 |
| CHEMBL122054 | — | — | 1 | 5.82 |
| CHEMBL122313 | — | — | 1 | 5.80 |
| CHEMBL333463 | — | — | 1 | 5.75 |
| CHEMBL122082 | — | — | 1 | 4.85 |
| CHEMBL125484 | — | — | 1 | 4.78 |
| CHEMBL121886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL293206 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL121771 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL122054 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL122313 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL333463 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL122082 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL125484 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL121886 | — | IC50 | > | 30000.0 | nM | - |