Assay Detail
Binding
CHEMBL697185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Cerebellum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (CHEMBL3904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5, 6-trisphosphate: aspects of their structure-activity relationship to biologically active inositol phosphates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.34 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23552 | — | — | 1 | 8.54 |
| CHEMBL283791 | — | — | 1 | 8.21 |
| CHEMBL281132 | — | — | 1 | 7.36 |
| CHEMBL282059 | — | — | 1 | 6.37 |
| CHEMBL23050 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23552 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL283791 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL281132 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL282059 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL23050 | — | IC50 | = | 620.0 | nM | 6.21 |