Assay Detail
Binding
CHEMBL697202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory potency compared to TNF-alpha induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Endothelial cell |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.21 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116070 | — | — | 1 | 8.52 |
| CHEMBL117279 | — | — | 1 | 8.30 |
| CHEMBL118074 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116070 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL117279 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL118074 | — | IC50 | = | 15.0 | nM | 7.82 |