Assay Detail
Binding
CHEMBL697246
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Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extract
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.40 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.30 |
| CHEMBL316183 | — | — | 1 | 7.31 |
| CHEMBL82931 | — | — | 1 | 7.13 |
| CHEMBL314643 | — | — | 1 | 6.76 |
| CHEMBL312098 | — | — | 1 | 6.60 |
| CHEMBL84395 | — | — | 1 | 6.55 |
| CHEMBL81522 | — | — | 1 | 6.52 |
| CHEMBL82989 | — | — | 1 | 6.10 |
| CHEMBL312400 | — | — | 1 | 5.93 |
| CHEMBL83750 | — | — | 1 | 5.77 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 5.70 |
| CHEMBL84288 | — | — | 1 | 5.59 |
| CHEMBL82382 | — | — | 1 | 4.98 |
| CHEMBL312253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL316183 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL82931 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL314643 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL312098 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL84395 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL81522 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL82989 | — | IC50 | = | 788.0 | nM | 6.10 |
| CHEMBL312400 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL83750 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL314389 | OXAMFLATIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL84288 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL82382 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL312253 | — | IC50 | > | 100000.0 | nM | - |