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Assay Detail

CHEMBL697290

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Mai A, Massa S, Pezzi R, Rotili D, Loidl P, Brosch G.
J Med Chem (2003) 46 : 4826 -4829
PubMed 14584932 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.09 6.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274445 TRAPOXIN A 1 6.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274445 TRAPOXIN A EC50 = 820.0 nM 6.09