Assay Detail
Binding
CHEMBL697291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.59 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144205 | — | — | 1 | 6.96 |
| CHEMBL145110 | — | — | 1 | 5.72 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.22 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 4.44 |
| CHEMBL356769 | TUBACIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144205 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL145110 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL99 | TRICHOSTATIN | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL343448 | ROMIDEPSIN | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL356769 | TUBACIN | EC50 | = | 217000.0 | nM | - |