Assay Detail
Binding
CHEMBL697294
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Inhibition of in vitro enzyme activity measured in a highly purified maize Histone deacetylase 2 preparation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.52 |
| CHEMBL111993 | — | — | 1 | 7.46 |
| CHEMBL113337 | — | — | 1 | 7.40 |
| CHEMBL110906 | — | — | 1 | 7.10 |
| CHEMBL264629 | — | — | 1 | 6.92 |
| CHEMBL113095 | — | — | 1 | 6.85 |
| CHEMBL113003 | — | — | 1 | 6.68 |
| CHEMBL323695 | — | — | 1 | 6.60 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 6.50 |
| CHEMBL320038 | — | — | 1 | 6.48 |
| CHEMBL111919 | — | — | 1 | 6.47 |
| CHEMBL331150 | — | — | 1 | 6.44 |
| CHEMBL419029 | — | — | 1 | 6.42 |
| CHEMBL46941 | — | — | 1 | 6.30 |
| CHEMBL326617 | — | — | 1 | 6.28 |
| CHEMBL115271 | — | — | 1 | 6.16 |
| CHEMBL325733 | — | — | 1 | 6.12 |
| CHEMBL109960 | — | — | 1 | 6.12 |
| CHEMBL112728 | — | — | 1 | 6.07 |
| CHEMBL112652 | — | — | 1 | 6.05 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.00 |
| CHEMBL326022 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL111993 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL113337 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL110906 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL264629 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL113095 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL113003 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL323695 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL320038 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL111919 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL331150 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL419029 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL46941 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL326617 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL115271 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL325733 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL109960 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL112728 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL112652 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL326022 | — | IC50 | = | 1100.0 | nM | 5.96 |