Assay Detail
Binding
CHEMBL697297
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Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extracts
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.57 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.14 |
| CHEMBL140525 | — | — | 1 | 6.70 |
| CHEMBL336935 | — | — | 1 | 6.57 |
| CHEMBL141909 | — | — | 1 | 6.05 |
| CHEMBL343717 | — | — | 1 | 5.85 |
| CHEMBL137875 | — | — | 1 | 5.23 |
| CHEMBL139192 | — | — | 1 | 5.11 |
| CHEMBL139193 | — | — | 1 | 4.96 |
| CHEMBL141082 | — | — | 1 | 4.72 |
| CHEMBL337584 | — | — | 1 | 4.58 |
| CHEMBL141885 | — | — | 1 | 4.39 |
| CHEMBL138293 | — | — | 1 | - |
| CHEMBL138626 | — | — | 1 | - |
| CHEMBL138090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL140525 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL336935 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL141909 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL343717 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL137875 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL139192 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL139193 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL141082 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL337584 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL141885 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL138293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL138626 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL138090 | — | IC50 | > | 100000.0 | nM | - |