Assay Detail
Binding
CHEMBL697372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability of compound to displace [3H]AMPA from Ionotropic glutamate receptor AMPA in rat cerebral cortex synaptic membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.39 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310286 | — | — | 1 | 6.60 |
| CHEMBL432748 | — | — | 1 | 5.89 |
| CHEMBL311831 | — | — | 1 | 5.01 |
| CHEMBL307267 | — | — | 1 | 5.01 |
| CHEMBL80594 | — | — | 1 | 4.94 |
| CHEMBL77569 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310286 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL432748 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL311831 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL307267 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL80594 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL77569 | — | Ki | = | 12500.0 | nM | 4.90 |