Assay Detail
Binding
CHEMBL697375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Ionotropic glutamate receptor AMPA was determined by the ability to displace [3H]AMPA in rat cortical membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.93 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9790 | — | — | 1 | 6.44 |
| CHEMBL50267 | — | — | 1 | 6.30 |
| CHEMBL317841 | — | — | 1 | 6.16 |
| CHEMBL318226 | — | — | 1 | 5.92 |
| CHEMBL96426 | — | — | 1 | 5.68 |
| CHEMBL96809 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9790 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL50267 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL317841 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL318226 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL96426 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL96809 | — | Ki | = | 8000.0 | nM | 5.10 |