Assay Detail
Functional
CHEMBL697445
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Tested for induction of cellular death in Human ZNS SF-268 tumor cell line in Propidium Iodide Monolayer Assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SF-268 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.38 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116173 | — | — | 1 | 7.52 |
| CHEMBL112192 | — | — | 1 | 7.40 |
| CHEMBL321632 | — | — | 1 | 6.21 |
| CHEMBL112385 | — | — | 1 | 6.05 |
| CHEMBL115488 | — | — | 1 | 6.01 |
| CHEMBL115360 | — | — | 1 | 5.94 |
| CHEMBL324797 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116173 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL112192 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL321632 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL112385 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL115488 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL115360 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL324797 | — | IC50 | = | 2970.0 | nM | 5.53 |