Assay Detail
Functional
CHEMBL697452
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In vitro inhibition of inducible vascular cell adhesion molecule-1 (VCAM-1) expression in Human aortic endothelial cells (HAEC)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Lead discovery of alpha,beta-unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.04 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165058 | (ETHENYLSULFONYL)BENZENE | — | 1 | 5.70 |
| CHEMBL288134 | — | — | 1 | 5.70 |
| CHEMBL349894 | — | — | 1 | 5.40 |
| CHEMBL163642 | — | — | 1 | 5.40 |
| CHEMBL349205 | — | — | 1 | 5.30 |
| CHEMBL162813 | — | — | 1 | 5.22 |
| CHEMBL163172 | — | — | 1 | 5.16 |
| CHEMBL162363 | — | — | 1 | 5.00 |
| CHEMBL164567 | — | — | 1 | 4.92 |
| CHEMBL163849 | — | — | 1 | 4.85 |
| CHEMBL163224 | — | — | 1 | 4.77 |
| CHEMBL349476 | — | — | 1 | 4.77 |
| CHEMBL164219 | — | — | 1 | 4.70 |
| CHEMBL162681 | — | — | 1 | 4.64 |
| CHEMBL351458 | — | — | 1 | 4.55 |
| CHEMBL350539 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165058 | (ETHENYLSULFONYL)BENZENE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL288134 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL349894 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL163642 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL349205 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL162813 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL163172 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL162363 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL164567 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL163849 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL163224 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL349476 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL164219 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL162681 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL351458 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL350539 | — | IC50 | = | 29000.0 | nM | 4.54 |