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Assay Detail

CHEMBL697497

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of histone deacetylase (HDAC) activity in DU-145 nuclear extracts
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.
Lu Q, Yang YT, Chen CS, Davis M, Byrd JC, Etherton MR, Umar A, Chen CS.
J Med Chem (2004) 47 : 467 -474
PubMed 14711316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.76 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL143336 1 7.36
CHEMBL356824 1 6.96
CHEMBL142048 1 6.28
CHEMBL356579 1 6.17
CHEMBL347734 1 5.92
CHEMBL142254 1 5.82
CHEMBL142155 1 5.80
CHEMBL143674 1 5.60
CHEMBL143102 1 5.44
CHEMBL358352 1 5.37
CHEMBL142440 1 5.30
CHEMBL141940 1 5.28
CHEMBL359137 1 5.22
CHEMBL142150 1 4.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL143336 IC50 = 44.0 nM 7.36
CHEMBL356824 IC50 = 110.0 nM 6.96
CHEMBL142048 IC50 = 530.0 nM 6.28
CHEMBL356579 IC50 = 670.0 nM 6.17
CHEMBL347734 IC50 = 1200.0 nM 5.92
CHEMBL142254 IC50 = 1500.0 nM 5.82
CHEMBL142155 IC50 = 1600.0 nM 5.80
CHEMBL143674 IC50 = 2500.0 nM 5.60
CHEMBL143102 IC50 = 3600.0 nM 5.44
CHEMBL358352 IC50 = 4300.0 nM 5.37
CHEMBL142440 IC50 = 5000.0 nM 5.30
CHEMBL141940 IC50 = 5200.0 nM 5.28
CHEMBL359137 IC50 = 6000.0 nM 5.22
CHEMBL142150 IC50 = 80000.0 nM 4.10