Assay Detail
Binding
CHEMBL697550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human inosine-5'-monophosphate dehydrogenase 2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.51 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304087 | MERIMEPODIB | 2.0 | 1 | 8.00 |
| CHEMBL68075 | — | — | 1 | 7.96 |
| CHEMBL64830 | — | — | 1 | 7.92 |
| CHEMBL67036 | — | — | 1 | 7.89 |
| CHEMBL66614 | — | — | 1 | 7.89 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.85 |
| CHEMBL63158 | — | — | 1 | 7.82 |
| CHEMBL302967 | — | — | 1 | 7.77 |
| CHEMBL306453 | — | — | 1 | 7.75 |
| CHEMBL64639 | — | — | 1 | 7.70 |
| CHEMBL417047 | — | — | 1 | 7.70 |
| CHEMBL305977 | — | — | 1 | 7.66 |
| CHEMBL302748 | — | — | 1 | 7.64 |
| CHEMBL67346 | — | — | 1 | 7.60 |
| CHEMBL261978 | — | — | 1 | 7.57 |
| CHEMBL65826 | — | — | 1 | 7.52 |
| CHEMBL67794 | — | — | 1 | 7.16 |
| CHEMBL302558 | — | — | 1 | 7.07 |
| CHEMBL65962 | — | — | 1 | 7.07 |
| CHEMBL430981 | — | — | 1 | 7.01 |
| CHEMBL305786 | — | — | 1 | 6.98 |
| CHEMBL66012 | — | — | 1 | 6.94 |
| CHEMBL307084 | — | — | 1 | 6.90 |
| CHEMBL66564 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304087 | MERIMEPODIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL68075 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL64830 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL67036 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL66614 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL63158 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL302967 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL306453 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL64639 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL417047 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL305977 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL302748 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL67346 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL261978 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL65826 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL67794 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL302558 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL65962 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL430981 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL305786 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL66012 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL307084 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL66564 | — | IC50 | = | 141.0 | nM | 6.85 |