Assay Detail
Functional
CHEMBL697576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of nuclear factor of activated T-cells (NFAT) mediated transcription of beta-galactosidase in J.NFATZ.1 cells
53
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T-cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel inhibitors of the nuclear factor of activated T cells (NFAT)-mediated transcription of beta-galactosidase: potential immunosuppressive and antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 6.52 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314231 | — | — | 5 | 8.59 |
| CHEMBL85752 | — | — | 1 | 8.22 |
| CHEMBL264865 | — | — | 1 | 8.10 |
| CHEMBL84597 | — | — | 1 | 7.67 |
| CHEMBL315970 | — | — | 1 | 7.58 |
| CHEMBL83355 | — | — | 1 | 7.12 |
| CHEMBL316397 | — | — | 1 | 7.05 |
| CHEMBL313093 | — | — | 1 | 7.05 |
| CHEMBL87829 | — | — | 1 | 7.05 |
| CHEMBL540438 | — | — | 1 | 6.85 |
| CHEMBL82854 | — | — | 1 | 6.82 |
| CHEMBL87644 | — | — | 1 | 6.78 |
| CHEMBL87704 | — | — | 1 | 6.73 |
| CHEMBL313050 | — | — | 1 | 6.72 |
| CHEMBL87539 | — | — | 1 | 6.65 |
| CHEMBL87388 | — | — | 1 | 6.62 |
| CHEMBL85551 | — | — | 1 | 6.58 |
| CHEMBL313065 | — | — | 1 | 6.58 |
| CHEMBL314018 | — | — | 1 | 6.56 |
| CHEMBL420602 | — | — | 1 | 6.56 |
| CHEMBL87691 | — | — | 1 | 6.51 |
| CHEMBL87871 | — | — | 1 | 6.51 |
| CHEMBL87259 | — | — | 1 | 6.50 |
| CHEMBL315281 | — | — | 1 | 6.44 |
| CHEMBL83027 | — | — | 1 | 6.42 |
| CHEMBL315295 | — | — | 1 | 6.36 |
| CHEMBL420968 | — | — | 1 | 6.36 |
| CHEMBL86589 | — | — | 1 | 6.20 |
| CHEMBL86929 | — | — | 1 | 6.19 |
| CHEMBL86462 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314231 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL314231 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL85752 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL314231 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL264865 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL314231 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL84597 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL315970 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL314231 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL83355 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL87829 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL313093 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL316397 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL540438 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL82854 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL87644 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL87704 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL313050 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL87539 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL87388 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL85551 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL313065 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL420602 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL314018 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL87691 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL87871 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL87259 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL315281 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL83027 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL315295 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL420968 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL86589 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL86929 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL86462 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL313539 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL85934 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL87507 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL85590 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL87556 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL314031 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL83076 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL87434 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL88021 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL313210 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL315759 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL423860 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL314676 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL85922 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL82795 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL405687 | — | IC50 | = | 4030.0 | nM | 5.39 |