Assay Detail
Functional
CHEMBL697592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tumor necrosis factor-alpha release from activated human monocyte cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.25 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54988 | — | — | 1 | 8.70 |
| CHEMBL429356 | — | — | 1 | 8.10 |
| CHEMBL55203 | — | — | 1 | 7.96 |
| CHEMBL54767 | — | — | 1 | 7.92 |
| CHEMBL301201 | — | — | 1 | 7.64 |
| CHEMBL301448 | — | — | 1 | 7.62 |
| CHEMBL300395 | — | — | 1 | 7.47 |
| CHEMBL56406 | — | — | 1 | 7.28 |
| CHEMBL53710 | — | — | 1 | 7.22 |
| CHEMBL55046 | — | — | 1 | 7.05 |
| CHEMBL445354 | — | — | 1 | 6.87 |
| CHEMBL54361 | — | — | 1 | 6.78 |
| CHEMBL299332 | — | — | 1 | 6.70 |
| CHEMBL52712 | — | — | 1 | 6.52 |
| CHEMBL417930 | — | — | 1 | 6.24 |
| CHEMBL54590 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54988 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL429356 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL55203 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL54767 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL301201 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL301448 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL300395 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL56406 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL53710 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL55046 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL445354 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL54361 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL299332 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL52712 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL417930 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL54590 | — | IC50 | = | 1300.0 | nM | 5.89 |